Explore Top-Quality Chlorotrimethylsilane (CAS 75-77-4) with Aure Chemical
Aure Chemical is a premier global supplier of high-quality Chlorotrimethylsilane (Me₃SiCl), commonly known as Trimethylsilyl Chloride (TMCS). Identified by its CAS number 75-77-4, this organosilicon compound is a colorless, fuming liquid with a strong, irritating odor. Chlorotrimethylsilane is an exceptionally versatile and powerful silylating reagent in organic synthesis. It plays an indispensable role in protecting a wide array of functional groups (like alcohols, amines, and carboxylic acids) as their trimethylsilyl ethers or derivatives, making them inert to various reactions. Beyond protection, it's widely used for introducing the trimethylsilyl group into molecules, facilitating complex transformations in the manufacturing of pharmaceuticals, agrochemicals, and silicone-based intermediates. Due to its reactivity with moisture and corrosive nature, handling and transportation of Chlorotrimethylsilane require meticulous care and adherence to strict safety protocols. Aure Chemical's unwavering commitment to excellence ensures that our Chlorotrimethylsilane meets the stringent purity and performance requirements for your most demanding industrial and laboratory applications, guaranteeing consistency, safety, and reliability.
Product Overview & Key Properties
Chlorotrimethylsilane (CAS No. 75-77-4) is meticulously produced and rigorously tested to meet stringent quality standards. We ensure exceptional purity and consistent performance, essential for your critical applications:
| CAS No.: | 75-77-4 |
| EC No.: | 200-900-5 |
| Linear Formula: | (CH₃)₃SiCl |
| Molecular Weight: | 108.64 |
| Appearance: | Clear, colorless, fuming liquid. |
| Odor: | Pungent odor. |
| Melting Point: | −40 °C(lit.) |
| Boiling point | 57 °C(lit.) |
| Density: | 0.857 g/mL at 25 °C |
| Reactivity: | Reacts vigorously with water (hydrolyzes to hexamethyldisiloxane and hydrochloric acid), alcohols, amines, and other protic solvents. |
| Flammability: | Flammable liquid and vapor. |
| Corrosivity: | Corrosive to metals in the presence of moisture and to organic tissues. |
| RIDADR: | UN 2924 3/PG 2 |
| Chemical Structure: |  |
Our commitment to delivering high-purity Chlorotrimethylsilane ensures a reliable and efficient component for your critical processes, offering consistent quality for diverse industrial needs, while prioritizing uncompromising safety in handling and logistics.
Primary Applications of Chlorotrimethylsilane
Chlorotrimethylsilane's unique reactivity and ability to introduce the trimethylsilyl group make it an indispensable reagent with extensive applications across various chemical synthesis pathways:
Protecting Group:
One of its most widespread uses is as a protecting group for various functional groups in organic synthesis. It efficiently converts alcohols, phenols, carboxylic acids, and amines into their trimethylsilyl derivatives, which are often more stable, volatile, or unreactive to specific reagents, allowing for selective transformations elsewhere in the molecule.
Silylating Agent:
It acts as a versatile silylating agent, introducing the trimethylsilyl group (Me₃Si– ) into organic molecules. This can modify physical properties, enhance solubility, or facilitate subsequent reactions.
Pharmaceutical Manufacturing:
Chlorotrimethylsilane is a crucial intermediate and reagent in the synthesis of numerous active pharmaceutical ingredients (APIs) and their precursors. Its role in protecting sensitive groups and enabling specific reactions is vital in complex drug synthesis routes.
Agrochemical Production:
It is widely employed in the synthesis of various agrochemicals, including pesticides, herbicides, and plant growth regulators, where silylation plays a role in modifying reactivity or stability.
Analytical Chemistry:
Used in analytical chemistry for derivatization, particularly to increase the volatility of polar compounds (like amino acids, sugars) for gas chromatography (GC) analysis, enabling their detection and quantification.
Production of Silicone Intermediates:
Serves as a raw material or intermediate in the synthesis of other silicone compounds, including silanes, siloxanes, and specialty silicone polymers.
Catalyst and Reagent:
In some reactions, it can function as a mild Lewis acid catalyst or as a source of chloride ions.
Why Choose Aure Chemical for Your Chlorotrimethylsilane Supply?
Aure Chemical is dedicated to providing superior chemical solutions and unparalleled customer support. By partnering with us for your Chlorotrimethylsilane requirements, you benefit from:
Exceptional Purity & Consistent Quality: Our Chlorotrimethylsilane is manufactured to stringent purity specifications, crucial for optimizing performance and selectivity in sensitive organic synthesis reactions, particularly in pharmaceutical and fine chemical production.
Uncompromising Safety & Compliance: Given the hazards associated with Chlorotrimethylsilane, Aure Chemical maintains world-class safety standards. Our manufacturing, storage, and transportation protocols are meticulously designed to adhere strictly to international safety regulations and best practices for handling highly reactive, flammable, and corrosive liquids.
Reliable Global Supply Chain: We maintain a robust and efficient global supply network, guaranteeing timely and secure delivery of this critical chemical to your facilities worldwide, with specialized logistics for hazardous liquids.
Expert Technical & Safety Support: Our dedicated team of experienced chemists and highly trained safety specialists is readily available to offer comprehensive guidance on product application, stringent safe handling procedures, emergency response planning, and optimal storage conditions for Chlorotrimethylsilane.
Commitment to Quality & Responsible Stewardship: We adhere to the highest industry standards for quality management, environmental responsibility, and product stewardship across all our operations, ensuring peace of mind for our clients and the responsible management of hazardous chemicals.
Choose Aure Chemical for a trustworthy and dependable supply of high-quality Chlorotrimethylsilane. We're ready to support your most demanding and innovative chemical processes with an unwavering commitment to safety and excellence.
Packaging, Transportation & Storage Solutions
At Aure Chemical, we understand the critical importance of rigorous packaging, transportation, and storage for chemical products. To ensure the safety and integrity of the products you purchase, and to comply with international and national regulations, we provide the following general guidelines. Please note that each specific product has its own Safety Data Sheet (SDS), which contains the most detailed and authoritative information on packaging, transportation, and storage. We strongly advise you to consult and strictly adhere to the SDS for the respective product.
| I. Packaging Solutions | II. Transportation Solutions | III. Storage Solutions |
We utilize various UN (United Nations) certified packaging containers based on the chemical nature, hazard class, and transportation requirements of our products. Common packaging types include, but are not limited to: Steel Drums: Suitable for a wide range of liquid and solid products, especially flammable liquids. Plastic Drums/Jerricans: Primarily used for corrosive liquids like acids and bases, or substances incompatible with metal. Composite Drums: Combine the corrosion resistance of a plastic inner liner with the strength of a steel or fiber outer shell. IBCs (Intermediate Bulk Containers): Often referred to as "Tote Bins" or "Cubic Tanks," these are used for larger volumes of liquid or solid dangerous goods, offering efficient storage and transport solutions. Lined Bags or Fibre Drums: Primarily used for powdered or granular solids. Glass Bottles: Typically used as inner packaging for small quantities of high-purity or specialized chemicals, requiring additional absorbent material and sturdy outer packaging (e.g., wooden crates, fiberboard boxes). Steel Cylinders: Specifically designed and constructed as pressure vessels for the storage and transport of compressed, liquefied, or dissolved gases. Available in various capacities and pressure ratings, they are built to withstand high internal pressures and ensure the safe containment of gaseous substances.
All packaging undergoes stringent testing and complies with UN packaging performance levels to ensure product safety under normal transport conditions. | We strictly adhere to international and regional regulations for the transport of dangerous goods, ensuring full compliance and safety from our facility to your delivery point. Sea Freight (IMDG Code): We strictly comply with the International Maritime Dangerous Goods (IMDG) Code, using UN-certified containers and ensuring proper dangerous goods declaration, marking, and stowage. Air Freight (IATA DGR): We follow the International Air Transport Association (IATA) Dangerous Goods Regulations, which impose the strictest requirements for packaging, labeling, documentation, and quantity limitations. Road/Rail Transport (ADR/RID & Local Regulations): We comply with the European Agreement concerning the International Carriage of Dangerous Goods by Road (ADR), the Regulations concerning the International Carriage of Dangerous Goods by Rail (RID), and specific national/regional regulations to ensure safe land transport.
Regardless of the transport mode, we will provide the following essential documentation: Safety Data Sheet (SDS/MSDS): Provides product hazard information, safe handling guidelines, emergency measures, etc. Dangerous Goods Declaration (DGD): Detailed information on dangerous goods, packing group, UN number, etc., for carriers and relevant authorities. Other Necessary Certifications or Documents: Such as Certificates of Analysis (COA).
Upon receiving your shipment, please carefully verify the integrity of the packaging and the label information.
| Proper storage is crucial for maintaining product quality and ensuring operational safety. The following are general storage principles: Dedicated Areas: Dangerous chemicals should be stored in designated warehouses or areas that meet safety standards, away from residential zones and densely populated areas. Segregated Storage: Strictly classify and segregate products according to their hazard class to prevent incompatible substances from being stored together and causing dangerous reactions (e.g., acids and bases separated, flammables away from oxidizers). Good Ventilation: Storage areas should maintain good natural or forced ventilation to prevent the accumulation of hazardous gases or vapors. Temperature & Humidity Control: Control the temperature and humidity of the storage environment according to the recommendations in the SDS. Avoid direct sunlight and extreme temperatures. Fire and Explosion Prevention: Storage areas for flammable and explosive products should be equipped with adequate fire-fighting equipment, prohibit open flames, and ensure electrical equipment meets explosion-proof standards. Clear Labeling: All storage containers and areas should have clear, conspicuous hazard labels and warning signs. Spill Response: Storage areas should be equipped with appropriate spill response equipment and materials, and personnel should be familiar with emergency procedures. Regular Inspections: Periodically inspect the integrity of storage containers to ensure no leaks or damage, and verify label information. Away from Food and Drinking Water: Avoid cross-contamination.
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| Should you have any questions regarding the packaging, transportation, or storage of specific products, or require a customized solution, please do not hesitate to contact us. |
