High-Purity Palladium(II) Trifluoroacetate from Aure Chemical – Your Trusted Source
Palladium(II) trifluoroacetate, Pd(CF₃COO)₂ or Pd(TFA)₂, CAS No. 42196-31-6, is a highly reactive palladium(II) precatalyst renowned for its exceptional Lewis acidity and oxidizing power in modern organometallic transformations. Supplied by Aure Chemical as a brown to dark brown crystalline powder with high palladium content (approximately 31–32% Pd), this air-stable, hygroscopic compound exhibits superior solubility in organic solvents and serves as an efficient source of electrophilic Pd(II) species. Its strong electron-withdrawing trifluoroacetate ligands dramatically enhance catalytic activity in C–H activation, oxidative couplings, dehydrogenative processes, and selective functionalizations that are often challenging with less electrophilic Pd sources like Pd(OAc)₂. It is indispensable for advanced synthetic routes in pharmaceutical intermediates, natural product synthesis, and functional material development. Aure Chemical ensures rigorous purity control, low residual impurities, and secure palladium sourcing to deliver batch consistency and optimal performance in demanding research and industrial applications worldwide.
Basic Information of Palladium(II) Trifluoroacetate
Aure Chemical supplies Palladium(II) Trifluoroacetate as a premium Pd(II) precatalyst with verified palladium content and exceptional purity for high-reactivity C–H and oxidative transformations.
| CAS No. | 42196-31-6 |
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| EC No. | 255-718-7 |
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| Chemical Formula | Pd(C₂F₃O₂)₂ |
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| Molecular Weight | 332.44 g/mol |
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| Appearance | Brown to dark brown crystalline powder |
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| Odor | Odorless to slight acetic-like |
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| Melting point | Decomposes before melting (>200 °C) |
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| Boiling point | Not applicable (decomposes) |
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| Density | approx. 2.1–2.3 g/cm³ |
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| Solubility | Soluble in acetone, acetonitrile, THF, dichloromethane; sparingly soluble in water |
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| Nature (hazards) | Causes severe skin burns and eye damage, may cause allergic skin reaction, harmful if swallowed, toxic to aquatic life |
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| RIDADR | UN 3260, Corrosive solid, acidic, inorganic, n.o.s. (Palladium(II) trifluoroacetate), Class 8, Packing Group III |
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| Chemical Structure |  |
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Aure Chemical offers customizable options including purity grades (98%+ Pd basis), Pd content verification, moisture-protected packaging, and tailored batch sizes to suit your C–H activation, coupling, or scale-up requirements.
Primary Applications of Palladium(II) Trifluoroacetate
Palladium(II) Trifluoroacetate is a powerful electrophilic Pd(II) source, excelling in challenging C–H functionalizations and oxidative processes where enhanced Lewis acidity is critical.
C–H Activation & Functionalization
Enables highly selective direct C–H arylation, acetoxylation, olefination, and amidation of arenes, heterocycles, and aliphatic C–H bonds, providing efficient routes to complex molecules with minimal prefunctionalization.
Oxidative Couplings & Dehydrogenative Reactions
Catalyzes oxidative C–C, C–N, and C–O bond formations using air or oxidants, delivering atom-economical access to biaryls, enones, and heterocycles in fine chemical synthesis.
Allylic & Vinylic Functionalization
Promotes regioselective allylic oxidation, acetoxylation, and amination, offering superior control in the synthesis of natural products and pharmaceutical intermediates.
Pharmaceutical & Natural Product Synthesis
Widely applied in late-stage functionalization and key steps of complex API and natural product total synthesis, leveraging its high reactivity and functional group tolerance.
Catalyst Development & Mechanistic Studies
Serves as a standard electrophilic Pd(II) source for ligand screening, kinetic studies, and development of novel Pd-catalyzed oxidative systems in academic and industrial R&D.
Materials & Polymer Chemistry
Facilitates Pd-catalyzed modifications of polymers, aromatic frameworks, and functional materials requiring enhanced electrophilicity for selective transformations.
Why Choose Aure Chemical for Your Palladium(II) Trifluoroacetate Supply?
Select Aure Chemical as your reliable partner for Palladium(II) Trifluoroacetate, delivering exceptional reactivity, technical expertise, and stable palladium supply for demanding synthetic applications.
Superior Purity & Batch Consistency
Advanced quality controls ensure uniform Pd content, minimal impurities, and reproducible catalytic activity across production lots.
Secure Palladium Sourcing
Transparent, responsible procurement with inventory buffering to ensure supply reliability amid market fluctuations.
Technical Application Support
Experienced catalysis team provides reaction optimization, oxidant/ligand synergy advice, scale-up guidance, and troubleshooting for maximum efficiency.
Comprehensive Regulatory Compliance
Full documentation suite including Certificates of Analysis, REACH, RoHS, and detailed SDS to facilitate seamless global operations.
Sustainability Commitment
Ethical sourcing practices and precious metal recovery/recycling programs aligned with modern ESG requirements and circular economy goals.
Hazards Classification
GHS Classification: Skin Corrosion/Irritation (Category 1B); Serious Eye Damage (Category 1); Skin Sensitization (Category 1); Acute Toxicity, Oral (Category 4); Aquatic Chronic (Category 2)
Hazard Statements: H314: Causes severe skin burns and eye damage; H317: May cause an allergic skin reaction; H302: Harmful if swallowed; H411: Toxic to aquatic life with long lasting effects
UN Number: UN 3260
Hazard Class: 8 (Corrosive substances)
Packing Group: III
GHS05: Corrosive
GHS07: Exclamation mark (sensitizer, acute toxicity)
GHS09: Environment (aquatic toxicity)
