High-Purity Tetrakis(triphenylphosphine)palladium(0) from Aure Chemical – Your Trusted Source
Tetrakis(triphenylphosphine)palladium(0), Pd(PPh₃)₄, CAS No. 14221-01-3, is a classic and highly effective Pd(0) precatalyst renowned for its exceptional performance in modern cross-coupling chemistry. Supplied by Aure Chemical as a bright yellow to light yellow crystalline powder with high palladium content (approximately 9–10% Pd), this air-sensitive complex readily dissociates in solution to generate coordinatively unsaturated Pd(0) species, delivering outstanding activity and selectivity under mild conditions. It excels in Suzuki-Miyaura, Heck, Sonogashira, Stille, Negishi, and related C–C bond-forming reactions, particularly with sensitive or sterically demanding substrates, making it indispensable for pharmaceutical API synthesis, agrochemicals, OLED materials, and advanced fine chemicals. Aure Chemical provides rigorous purity control, low residual PPh₃, inert-atmosphere packaging, and secure palladium sourcing to ensure batch consistency, maximum catalytic potency, and reliable performance in research and industrial-scale operations worldwide.
Basic Information of Tetrakis(triphenylphosphine)palladium(0)
Aure Chemical supplies Tetrakis(triphenylphosphine)palladium(0) as a premium Pd(0) precatalyst with verified palladium content and exceptional purity for high-performance cross-coupling applications.
| CAS No. | 14221-01-3 |
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| EC No. | 238-086-9 |
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| Chemical Formula | Pd(P(C₆H₅)₃)₄ |
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| Molecular Weight | 1155.58 g/mol |
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| Appearance | Bright yellow to light yellow crystalline powder |
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| Odor | Odorless |
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| Melting point | 103–107 °C (decomposes) |
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| Boiling point | Not applicable (decomposes) |
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| Density | approx. 1.4 g/cm³ |
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| Solubility | Insoluble in water; soluble in benzene, toluene, THF, dichloromethane (air-sensitive solutions) |
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| Nature (hazards) | Harmful if swallowed, may cause long lasting harmful effects to aquatic life, air-sensitive |
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| RIDADR | Not regulated (not subject to transport regulations as hazardous material in many classifications) |
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| Chemical Structure |  |
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Aure Chemical provides customizable options including purity grades (99%+ Pd basis), packaging under inert atmosphere to maintain stability, and tailored batch sizes to suit your coupling or scale-up requirements.
Primary Applications of Tetrakis(triphenylphosphine)palladium(0)
Pd(PPh₃)₄ is a foundational Pd(0) precatalyst, delivering outstanding efficiency in classic and advanced cross-coupling reactions across multiple sectors.
Suzuki-Miyaura Cross-Coupling
Facilitates high-yield aryl-aryl and aryl-heteroaryl bond formation with excellent functional group tolerance, a cornerstone reaction in pharmaceutical and agrochemical intermediate synthesis.
Heck Reaction (Mizoroki-Heck Coupling)
Enables efficient vinylation of aryl halides with alkenes, providing stereoselective access to styrenes, cinnamates, and conjugated systems in fine chemicals and material intermediates.
Sonogashira Coupling
Catalyzes coupling of aryl/vinyl halides with terminal alkynes to form aryl-alkynes, widely used in the synthesis of pharmaceuticals, natural products, and conjugated polymers for electronics.
Stille Coupling
Supports carbon-carbon bond formation using organostannanes with high selectivity, offering excellent compatibility in complex molecule assembly for drug discovery and specialty chemicals.
Pharmaceutical API Synthesis
Serves as a key precatalyst in multistep syntheses of active pharmaceutical ingredients, providing mild conditions, high selectivity, and scalability for commercial production.
Material Science & OLED Development
Enables precise synthesis of ligands, monomers, and functional materials for organic electronics, phosphorescent emitters, and advanced polymers.
Why Choose Aure Chemical for Your Tetrakis(triphenylphosphine)palladium(0) Supply?
Partner with Aure Chemical for Tetrakis(triphenylphosphine)palladium(0) to benefit from superior quality, technical expertise, and dependable precious metal supply chain management.
High Purity & Air-Sensitive Stability
Specialized inert packaging and quality controls preserve compound integrity, minimizing oxidation and ensuring maximum catalytic activity upon use.
Secure Palladium Sourcing
Transparent, responsible procurement with inventory buffering to provide supply reliability and price stability in volatile palladium markets.
Technical Catalysis Support
Dedicated specialists offer reaction optimization, ligand/base screening, scale-up guidance, and troubleshooting to maximize yield and selectivity.
Comprehensive Regulatory Compliance
Full COA, REACH, RoHS, and detailed SDS documentation to facilitate seamless integration into global pharmaceutical and fine chemical operations.
Sustainability & Recycling Programs
Ethical sourcing practices and palladium recovery/recycling options aligned with ESG goals and sustainable chemistry principles.
Hazards Classification
GHS Classification: Acute Toxicity, Oral (Category 4); Aquatic Chronic (Category 4)
Hazard Statements: H302: Harmful if swallowed; H413: May cause long lasting harmful effects to aquatic life
UN Number: Not regulated
Hazard Class: Not classified as hazardous for transport
Packing Group: Not applicable
GHS07: Exclamation mark (acute toxicity)
GHS09: Environment (aquatic hazard)
