Palladium(II) acetate CAS 3375-31-3

High-Purity Palladium(II) Acetate from Aure Chemical – Your Trusted Source

Palladium(II) acetate, Pd(OAc)₂ or palladium diacetate, CAS No. 3375-31-3, is one of the most widely used palladium(II) precatalysts in modern synthetic organic chemistry. Supplied by Aure Chemical as a reddish-brown to brown crystalline powder with high palladium content (approximately 47% Pd), this air-stable, soluble compound serves as an efficient source of Pd(II) or Pd(0) species for a broad range of transformations. Renowned for its excellent activity, broad functional group tolerance, and operational simplicity, it is the preferred precursor for cross-coupling reactions (Heck, Suzuki, Sonogashira, Negishi), C–H functionalization, Buchwald-Hartwig amination/etherification, and carbonylative couplings essential to pharmaceutical, agrochemical, and fine chemical manufacturing. Aure Chemical delivers rigorous purity control, low trace metal impurities, and secure palladium sourcing to ensure batch consistency and optimal catalytic performance in research and industrial-scale processes worldwide.

Basic Information of Palladium(II) Acetate

Aure Chemical supplies Palladium(II) Acetate as a premium Pd(II) precatalyst with verified palladium content and exceptional purity for advanced synthetic applications.

CAS No.	3375-31-3
EC No.	222-164-4
Chemical Formula	C4H6O4Pd (monomeric); often trimeric in solid state
Molecular Weight	224.50 g/mol (monomer basis)
Appearance	Reddish-brown to brown crystalline powder
Odor	Slight acetic acid-like
Melting point	205–224 °C (decomposes)
Boiling point	Not applicable (decomposes)
Density	approx. 2.19 g/cm³
Solubility	Insoluble in water; soluble in acetic acid, benzene, toluene, acetone, chloroform
Nature (hazards)	Skin sensitizer, causes serious eye damage, very toxic to aquatic life with long lasting effects
RIDADR	UN 3077, Environmentally hazardous substance, solid, n.o.s. (Palladium(II) acetate), Class 9, Packing Group III
Chemical Structure

Aure Chemical offers customizable options including purity grades (98%+ or trace metals basis), Pd content verification, packaging under inert atmosphere, and tailored batch sizes to suit your synthesis or scale-up needs.

Primary Applications of Palladium(II) Acetate

Palladium(II) Acetate is a cornerstone precatalyst, readily reduced to active Pd(0) or functioning directly as Pd(II) in numerous high-impact palladium-catalyzed reactions.

1. Cross-Coupling Reactions
   Serves as the preferred Pd source for Suzuki-Miyaura, Heck, Sonogashira, Negishi, and Stille couplings, enabling efficient C–C bond formation in pharmaceutical and agrochemical intermediates.

2. C–H Activation & Functionalization
   Facilitates direct arylation, acetoxylation, olefination, and amidation of C–H bonds, providing atom-economical routes to complex molecules with reduced synthetic steps.

3. Buchwald-Hartwig Amination & Etherification
   Enables high-yielding C–N and C–O bond formation under mild conditions, critical for accessing nitrogen- and oxygen-containing pharmacophores in drug discovery.

4. Pharmaceutical API Synthesis
   Widely employed in multi-kilogram-scale production of active pharmaceutical ingredients, offering excellent selectivity, functional group compatibility, and process robustness.

5. Carbonylation & CO-Insertion Reactions
   Catalyzes carbonylative couplings, esterifications, and amidations, providing efficient access to carboxylic acid derivatives and heterocycles in fine chemical synthesis.

6. Catalyst Development & Mechanistic Studies
   Acts as a standard Pd(II) precursor for ligand screening, mechanistic investigations, and development of novel palladium catalytic systems in academic and industrial R&D.

Why Choose Aure Chemical for Your Palladium(II) Acetate Supply?

Select Aure Chemical as your reliable partner for Palladium(II) Acetate, delivering premium quality, technical expertise, and stable palladium supply for your catalytic needs.

• Superior Purity & Batch Consistency
  Advanced quality controls guarantee uniform Pd content, minimal impurities, and reproducible catalytic activity across production lots.

• Secure Palladium Sourcing
  Transparent, responsible procurement of palladium with inventory management to ensure supply reliability amid market fluctuations.

• Technical Application Support
  Experienced catalysis team provides reaction optimization, ligand synergy advice, scale-up guidance, and troubleshooting for maximum process efficiency.

• Comprehensive Regulatory Compliance
  Full documentation suite including Certificates of Analysis, REACH, RoHS, and detailed SDS to facilitate seamless integration into global operations.

• Sustainability Commitment
  Ethical sourcing practices and precious metal recovery/recycling programs aligned with modern ESG requirements and circular economy goals.

Hazards Classification

• GHS Classification: Skin Sensitization (Category 1); Serious Eye Damage (Category 1); Aquatic Acute (Category 1); Aquatic Chronic (Category 1)

• Hazard Statements: H317: May cause an allergic skin reaction; H318: Causes serious eye damage; H410: Very toxic to aquatic life with long lasting effects

• UN Number: UN 3077

• Hazard Class: 9 (Miscellaneous dangerous substances and articles)

• Packing Group: III