[1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) CAS 72287-26-4

High-Purity [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) from Aure Chemical – Your Trusted Source

[1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II), commonly abbreviated as Pd(dppf)Cl₂, CAS No. 72287-26-4, is one of the most effective and widely adopted Pd(II) precatalysts in modern cross-coupling chemistry. Supplied by Aure Chemical as a red to reddish-brown crystalline powder with high palladium content (approximately 13–14% Pd), this air-stable complex features the strongly electron-donating and chelating dppf ligand, which imparts exceptional activity and stability to the active Pd(0) species generated in situ. Renowned for its superior performance in Suzuki-Miyaura, Negishi, Stille, Kumada, and Buchwald-Hartwig couplings, it excels with challenging substrates such as heteroaryl halides, sterically hindered partners, and aryl chlorides under mild conditions. Its broad functional group tolerance and robustness make it indispensable for pharmaceutical API synthesis, agrochemicals, and advanced materials development. Aure Chemical delivers stringent purity control, low residual impurities, and secure palladium sourcing to ensure batch-to-batch consistency and optimal catalytic efficiency in research and industrial-scale processes worldwide.

Basic Information of [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II)

Aure Chemical supplies [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) as a premium Pd(II) precatalyst with verified palladium content and exceptional purity for high-performance cross-coupling applications.

CAS No.	72287-26-4
EC No.	276-642-4
Chemical Formula	C₃₄H₂₈Cl₂FeP₂Pd
Molecular Weight	731.70 g/mol
Appearance	Red to reddish-brown crystalline powder
Odor	Odorless
Melting point	Decomposes >260 °C
Boiling point	Not applicable (decomposes)
Density	approx. 1.7–1.9 g/cm³
Solubility	Insoluble in water; soluble in dichloromethane, chloroform, toluene, THF
Nature (hazards)	Harmful if swallowed, may cause long lasting harmful effects to aquatic life, air-sensitive in solution
RIDADR	Not regulated (not subject to transport regulations as hazardous material in many classifications)
Chemical Structure

Aure Chemical offers customizable options including purity grades (99%+ Pd basis), solvent adducts (e.g., CH₂Cl₂), air-sensitive packaging under inert atmosphere, and specific batch sizes to preserve activity for your coupling or scale-up needs.

Primary Applications of [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II)

Pd(dppf)Cl₂ remains a gold-standard precatalyst, delivering superior performance in challenging cross-coupling reactions due to the unique electronic and steric properties of the dppf ligand.

1. Suzuki-Miyaura Cross-Coupling
   Excels in coupling aryl/heteroaryl boronic acids with aryl/heteroaryl chlorides, bromides, and triflates, offering high yields and excellent functional group tolerance in pharmaceutical intermediate synthesis.

2. Negishi & Kumada Couplings
   Enables efficient C–C bond formation with organozinc or organomagnesium reagents, particularly effective for sterically hindered or electron-rich partners in fine chemical production.

3. Buchwald-Hartwig Amination & Etherification
   Facilitates robust C–N and C–O bond construction with amines, amides, alcohols, and phenols, providing access to key pharmacophores under mild conditions.

4. Stille & Hiyama Couplings
   Supports tin- and silicon-based cross-couplings with high selectivity, useful for synthesizing conjugated systems and complex natural product fragments.

5. Pharmaceutical API Manufacturing
   Widely adopted in multi-kilogram-scale Pd-catalyzed steps for active pharmaceutical ingredients, delivering process robustness, scalability, and regulatory-friendly performance.

6. Catalyst Development & Ligand Screening
   Serves as a reliable Pd source for evaluating new ligands, mechanistic studies, and development of advanced palladium catalytic systems in academic and industrial R&D.

Why Choose Aure Chemical for Your [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) Supply?

Partner with Aure Chemical for Pd(dppf)Cl₂ to access benchmark coupling performance, technical expertise, and dependable palladium supply tailored to your synthetic needs.

• Superior Purity & Ligand Integrity
  Stringent quality controls ensure high Pd content, minimal free dba or impurities, and preserved dppf coordination for maximum catalytic activity and reproducibility.

• Air-Sensitive Handling Expertise
  Specialized inert-atmosphere packaging and storage preserve compound stability from production to delivery, minimizing degradation in sensitive applications.

• Secure Precious Metal Supply Chain
  Transparent, responsible palladium procurement with inventory strategies to provide supply continuity and price stability.

• Technical Catalysis Support
  Dedicated specialists offer reaction optimization, ligand/base screening, scale-up guidance, and troubleshooting to enhance yield and selectivity.

• Regulatory & Sustainability Compliance
  Comprehensive COA, REACH, RoHS, SDS documentation and palladium recycling programs aligned with global standards and ESG commitments.

Hazards Classification

• GHS Classification: Acute Toxicity, Oral (Category 4); Aquatic Chronic (Category 4)

• Hazard Statements: H302: Harmful if swallowed; H413: May cause long lasting harmful effects to aquatic life

• UN Number: Not regulated

• Hazard Class: Not classified as hazardous for transport

• Packing Group: Not applicable