What Are Amino PEG Derivatives?
Amino PEG derivatives are polyethylene glycol or oligoethylene glycol structures that incorporate at least one primary amino functional group. The products featured in this application article are primarily amino-hydroxy PEG linkers, also known as NH2-PEG-OH intermediates. These molecules combine a hydrophilic PEG chain with a reactive primary amine at one terminus and a terminal hydroxyl group at the other.
The primary amino group enables participation in coupling reactions such as amide bond formation with activated carboxylic acids, reactions with NHS esters, and reductive amination with aldehydes or ketones. The terminal hydroxyl group provides an additional handle for further functionalization, including protection strategies, esterification, etherification, or conversion into other reactive moieties. This dual functionality makes amino-hydroxy PEG linkers versatile building blocks in research-stage synthesis.
Common examples within this series include 2-(2-(2-Aminoethoxy)ethoxy)ethanol, Amino-PEG4-alcohol, 14-Amino-3,6,9,12-tetraoxatetradecanol, Amino-PEG6-alcohol, Amino-PEG7-alcohol, and Amino-PEG8-alcohol. These are defined, discrete molecules with specific CAS numbers rather than polydisperse high-molecular-weight PEG polymers. Their precise chain lengths and functional group placement support reproducible results in specialty synthesis and research applications.
Why Amino PEG Derivatives Are Used in Bioconjugation Research
Amino PEG derivatives function as hydrophilic linkers and flexible molecular spacers in research-stage bioconjugation and specialty synthesis programs. The combination of a hydrophilic PEG backbone with a primary amine allows researchers to introduce flexible, water-compatible segments while providing a convenient site for covalent attachment to molecules bearing complementary reactive groups.
In research settings, these NH2-PEG-OH intermediates are employed to connect or modify molecular components containing activated carboxylic acids, NHS esters, aldehydes, or ketones. The amino group supports amide coupling and reductive amination protocols commonly used in the construction of research-stage molecular constructs. The terminal hydroxyl group can remain available for subsequent transformations or be used in orthogonal protection strategies during multi-step synthesis.
Because of their defined structure and tunable chain length, amino PEG derivatives serve as reliable PEG linker building blocks when precise spacing between functional elements is required. They also act as precursors for preparing more complex functional PEG derivatives through further modification of either the amino or hydroxyl terminus. These characteristics position them as valuable intermediates within the broader family of PEG & Polyether Derivatives used in research and specialty chemical synthesis.
Amino PEG Derivatives for Surface Modification
Amino PEG derivatives are utilized as surface modification intermediates in research and specialty material development. The primary amine enables attachment to surfaces or materials presenting carboxylated, activated ester, epoxy, aldehyde, or other compatible functional groups through established coupling chemistries.
In research contexts, these linkers allow the introduction of hydrophilic PEG spacers onto polymer surfaces, nanoparticles, or other substrates. The PEG chain can help adjust surface properties such as wettability, steric stabilization, or compatibility with aqueous environments. The terminal hydroxyl group offers an additional site for further chemical elaboration or for controlled attachment of additional moieties after surface immobilization.
Selection of the appropriate chain length permits tuning of the distance between the surface and any subsequently attached components, as well as control over the overall hydrophilicity contributed by the PEG segment. These applications remain within the scope of research-stage surface functionalization and specialty synthesis rather than clinical or medical device development.
Chain Length and Application Direction
The number of ethylene glycol repeating units in amino PEG derivatives influences key physical and chemical properties relevant to research applications. Shorter chains, such as those in Amino-PEG4-alcohol and the related triethylene glycol-based structure, provide more compact spacing between the amino and hydroxyl groups along with lower viscosity and different solubility behavior. As chain length increases through Amino-PEG6-alcohol, Amino-PEG7-alcohol, and Amino-PEG8-alcohol, hydrophilicity generally strengthens, molecular flexibility improves, and the effective distance between the two functional termini increases.
These differences affect steric considerations in coupling reactions, the degree of hydration around the linker, and handling characteristics during synthesis or formulation work. Researchers typically select chain length based on the required spatial separation, desired balance of hydrophilicity, and compatibility with downstream reaction conditions or surface immobilization protocols. Members of this series are commonly selected for their useful solubility in water and many polar organic solvents, which supports their use across diverse research and specialty synthesis workflows.
| Product | CAS No. | Approximate Chain Type | Application Direction | Product Page |
|---|---|---|---|---|
| 2-(2-(2-Aminoethoxy)ethoxy)ethanol | 6338-55-2 | Amino-triethylene glycol (3 EO units) | Compact hydrophilic amino-hydroxy linker for short-distance spacing in research synthesis | 2-(2-(2-Aminoethoxy)ethoxy)ethanol CAS 6338-55-2 |
| Amino-PEG4-alcohol | 86770-74-3 | Amino-PEG4 (4 EO units) | Short flexible amino-hydroxy spacer for bioconjugation research and surface attachment | Amino-PEG4-alcohol CAS 86770-74-3 |
| 14-Amino-3,6,9,12-tetraoxatetradecanol | 34188-11-9 | Amino-PEG5 (5 EO units) | Moderate-length amino-hydroxy linker balancing hydrophilicity and molecular spacing | 14-Amino-3,6,9,12-tetraoxatetradecanol CAS 34188-11-9 |
| Amino-PEG6-alcohol | 39160-70-8 | Amino-PEG6 (6 EO units) | Extended hydrophilic amino-hydroxy spacer for research-stage coupling and surface work | Amino-PEG6-alcohol CAS 39160-70-8 |
| Amino-PEG7-alcohol | 1425973-14-3 | Amino-PEG7 (7 EO units) | Longer flexible linker providing increased spacing and stronger hydration in research applications | Amino-PEG7-alcohol CAS 1425973-14-3 |
| Amino-PEG8-alcohol | 352439-37-3 | Amino-PEG8 (8 EO units) | Extended amino-hydroxy PEG linker for applications requiring greater molecular distance and hydrophilicity | Amino-PEG8-alcohol CAS 352439-37-3 |
Selected Amino PEG Derivatives from Aure Chemical
Aure Chemical supplies a focused selection of amino-hydroxy PEG linkers suitable for research and specialty synthesis applications. Each product features a defined PEG chain length with a primary amino group and terminal hydroxyl functionality, enabling precise control in molecular design.
| Product Name | CAS No. | Functional Type | Typical Use Direction | Product Page |
|---|---|---|---|---|
| 2-(2-(2-Aminoethoxy)ethoxy)ethanol | 6338-55-2 | Amino-hydroxy PEG linker | Short-chain NH2-PEG-OH intermediate for compact spacing and further functionalization | 2-(2-(2-Aminoethoxy)ethoxy)ethanol CAS 6338-55-2 |
| Amino-PEG4-alcohol | 86770-74-3 | Amino-hydroxy PEG linker | Versatile short amino PEG alcohol for research coupling and surface modification studies | Amino-PEG4-alcohol CAS 86770-74-3 |
| 14-Amino-3,6,9,12-tetraoxatetradecanol | 34188-11-9 | Amino-hydroxy PEG linker | Moderate-chain amino PEG intermediate balancing flexibility and hydrophilicity | 14-Amino-3,6,9,12-tetraoxatetradecanol CAS 34188-11-9 |
| Amino-PEG6-alcohol | 39160-70-8 | Amino-hydroxy PEG linker | Extended amino-hydroxy linker for research bioconjugation and surface functionalization | Amino-PEG6-alcohol CAS 39160-70-8 |
| Amino-PEG7-alcohol | 1425973-14-3 | Amino-hydroxy PEG linker | Longer flexible amino PEG spacer for specialty synthesis requiring greater molecular distance | Amino-PEG7-alcohol CAS 1425973-14-3 |
| Amino-PEG8-alcohol | 352439-37-3 | Amino-hydroxy PEG linker | Extended-chain amino-hydroxy PEG for research applications needing strong hydrophilicity and spacing | Amino-PEG8-alcohol CAS 352439-37-3 |
How to Select Amino PEG Derivatives for Synthesis Projects
Successful amino PEG derivative selection starts with matching the required PEG chain length or number of ethylene glycol units to the desired molecular spacing and hydrophilicity. Shorter chains offer compact linkers with different handling properties, while longer chains provide greater flexibility and stronger hydration effects. The reactivity of the primary amino group and the presence of the terminal hydroxyl functionality are central considerations, as they determine compatibility with planned coupling reactions or further derivatization steps.
NH2-PEG-OH linker sourcing also requires evaluation of hydrophilicity and solubility requirements in the intended reaction medium or formulation. Compatibility with downstream reactions—such as amide coupling, reductive amination, or orthogonal modification of the hydroxyl group—should be assessed. Purity and impurity profile are particularly important in sensitive research-stage synthesis where trace impurities could affect coupling efficiency or product purity.
Confirmation via the correct CAS number ensures the precise chain length and isomer are obtained. Product specification documents, including target purity, water content, and appearance, help align material quality with project needs. Packaging preferences and shipping conditions should be discussed for moisture- or air-sensitive derivatives.
Required documentation such as COA, SDS, TDS, and specification sheets should be requested during the inquiry process. Clear communication of quantity, destination country or port, and intended research application enables suppliers to provide accurate availability and supporting information for amino PEG linker selection and PEG amine alcohol intermediate projects.
Related PEG & Polyether Derivatives Applications
Amino PEG derivatives form part of the interconnected family of PEG & Polyether Derivatives. Their hydroxyl-terminated structure allows them to serve as starting points or complements to other functional variants used in research and specialty synthesis.
Buyers working with amino-hydroxy PEG linkers often explore oligoethylene glycol derivatives as upstream hydroxyl building blocks or methoxy PEG derivatives when a non-reactive cap at one terminus is preferred. For projects requiring carboxylic acid functionality, carboxyl PEG acid derivatives provide complementary reactivity. Symmetric or crosslinking applications may call for diamino PEG linkers, while more complex research constructs frequently utilize PEG linker building blocks.
Together with the core PEG & Polyether Derivatives Supplier overview, these related families enable technical teams to select or design appropriate hydrophilic linkers and spacers for their specific research and specialty chemical synthesis objectives.
Why Source Amino PEG Derivatives from Aure Chemical?
Aure Chemical is a China-based specialty chemical supplier and exporter supporting global R&D and procurement teams in sourcing amino PEG derivatives and related PEG/polyether intermediates. Our team assists buyers in identifying suitable products by product name, CAS number, chain length, functional group placement, or intended research application.
When documentation is available, we can provide COA, SDS, TDS, or specification sheets to support quality systems and research documentation requirements. We handle inquiries from research samples through pilot and commercial quantities, considering packaging needs and international shipping logistics.
With experience in fine chemical export and specialty intermediates, Aure Chemical offers reliable communication and practical support for projects involving hydrophilic linkers, surface functionalization research, and specialty synthesis. We welcome detailed inquiries for amino PEG derivatives and related materials.
How to Send an Inquiry for Amino PEG Derivatives
To obtain accurate availability and quotation information for amino PEG derivatives, please include the following details in your inquiry:
Product name, such as Amino-PEG6-alcohol, or CAS number
Required purity or specification
Quantity needed, such as research sample, pilot, or commercial scale
Destination country or port
Intended research application or end use
Required documents, such as COA, SDS, TDS, or specification sheet
Packaging preference
Shipping method preference
Expected timeline
Our team will review your requirements and respond with current information on availability, documentation, and logistics.
Frequently Asked Questions
What are amino PEG derivatives used for?
Amino PEG derivatives serve as hydrophilic linkers and flexible spacers in research-stage bioconjugation and specialty synthesis. The primary amino group enables coupling reactions such as amide formation and reductive amination, while the terminal hydroxyl provides an additional site for further modification or orthogonal chemistry in molecular construction.
What is an NH2-PEG-OH linker?
An NH2-PEG-OH linker is an amino-hydroxy PEG intermediate featuring a primary amine at one end and a hydroxyl group at the other, connected by a defined polyethylene glycol chain. This dual functionality allows sequential or selective reactions and is widely used in research settings where both attachment capability and further derivatization potential are required.
How do amino PEG derivatives support bioconjugation research?
In research applications, amino PEG derivatives act as flexible, hydrophilic bridges that connect molecules bearing complementary reactive groups. The amino terminus supports amide coupling with activated carboxylic acids or NHS esters and reductive amination with carbonyl compounds, enabling the assembly of more complex research-stage constructs with controlled spacing and improved aqueous compatibility.
How are amino PEG derivatives used in surface modification?
Amino PEG derivatives function as surface modification intermediates in research by attaching to carboxylated, activated, epoxy, or aldehyde-functionalized surfaces through amine-based coupling chemistry. Once immobilized, the PEG chain introduces hydrophilicity and the terminal hydroxyl offers a site for additional chemical elaboration in specialty material development projects.
What is the difference between Amino-PEG4-alcohol and Amino-PEG8-alcohol?
Amino-PEG4-alcohol contains four ethylene glycol units and provides relatively compact spacing with lower viscosity. Amino-PEG8-alcohol contains eight units, offering greater molecular flexibility, stronger overall hydrophilicity, and increased distance between the amino and hydroxyl functional groups. Both share useful solubility behavior but differ in physical properties and steric behavior during use.
Can Aure Chemical provide COA and SDS for amino PEG derivatives?
When available, Aure Chemical can supply COA, SDS, TDS, and specification sheets for the amino PEG derivatives we source. Please specify your documentation requirements in the inquiry so we can confirm availability and provide the appropriate files.
What information is needed for an amino PEG derivative quotation?
Quotations depend on product identity, quantity, purity requirements, packaging specifications, destination, shipping method, and documentation needs. Providing clear details about the intended research application helps us deliver accurate availability information and relevant supporting documentation for your project.