Amino-PEG4-alcohol CAS 86770-74-3

Aure Chemical Supplies Amino-PEG4-alcohol CAS 86770-74-3 for PEG Linker and Specialty Synthesis

Amino-PEG4-alcohol (CAS 86770-74-3), also referred to as NH2-PEG4-OH, is a monodisperse bifunctional polyethylene glycol derivative. It features a primary amino group and a terminal hydroxyl group separated by a tetraethylene glycol chain, making it an effective molecular linker for a variety of synthetic applications.

This compound is commonly employed in fine chemical synthesis and pharmaceutical intermediate research, particularly where precise control over hydrophilic spacer length is required. Aure Chemical acts as a reliable sourcing partner, providing high-purity material along with essential documentation for global customers engaged in organic synthesis and bioconjugation projects.

Basic Information

CAS No.	86770-74-3
EC No.	846-679-4
Linear Formula	H₂N-(CH₂CH₂O)₄-H
Molecular Weight	193.24 g/mol
Appearance	Colorless to pale yellow viscous liquid or oil
Melting Point	Not available (typical reference)
Boiling point	301.6 ± 27.0 °C (Predicted)
Density	1.068 ± 0.06 g/cm³ (Predicted)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture. Recommended storage at -20°C under inert atmosphere.
Chemical Structure

Key Applications

• PEG linker intermediate: Provides a defined tetraethylene glycol spacer with terminal amino and hydroxyl groups for constructing bioconjugates and PROTAC linkers.

• Bioconjugation research: The primary amine enables efficient coupling to carboxylic acids, NHS esters and carbonyl groups in biomolecule modification studies.

• Fine chemical intermediate: Acts as a versatile building block in organic synthesis for introducing hydrophilic polyether chains into complex molecules.

• Process development: Supports custom synthesis and route optimization efforts in pharmaceutical and specialty chemical process research.

• Laboratory research: Widely used in medicinal chemistry laboratories for developing PEGylated compounds and studying structure-activity relationships.

Why Work with Aure Chemical for Amino-PEG4-alcohol

• Consistent product quality: High-purity Amino-PEG4-alcohol is sourced through established channels with routine quality coordination to meet fine chemical specifications.

• Flexible global supply: We support laboratory, pilot, and bulk procurement needs with stable export logistics and flexible shipping arrangements worldwide.

• SDS and COA support: Comprehensive product documentation including SDS and COA is available upon request to facilitate regulatory review and international procurement.

• Packaging and technical service: Responsive technical communication and assistance with appropriate packaging selection based on order quantity and product characteristics.

Packaging and Storage

• Packaging: Supplied in laboratory-scale sealed containers or sample bottles for small quantities; bulk quantities available in HDPE drums upon request. Customized packaging options can be discussed based on specific requirements.

• Storage: Store in tightly closed containers in a cool, dry, well-ventilated area away from direct sunlight. Long-term storage is best at -20°C under an inert atmosphere due to hygroscopic nature.

• Handling of opened containers: After opening, protect the product from moisture and air exposure. Use the contents promptly and reseal the container tightly for any remaining material.

Safety and Handling

• General handling: Handle in a well-ventilated area or chemical fume hood. Avoid unnecessary exposure and follow standard laboratory practices for handling organic compounds.

• Personal protection: Wear suitable protective gloves, safety glasses or goggles, and protective clothing to prevent skin and eye contact during handling.

• Documentation review: Consult the current Safety Data Sheet (SDS) before use, storage, or transportation to ensure appropriate precautions are observed.