Amino-PEG6-alcohol CAS 39160-70-8

Aure Chemical Supplies Amino-PEG6-alcohol CAS 39160-70-8 for PEG Linker and Specialty Synthesis

Amino-PEG6-alcohol (CAS 39160-70-8), also referred to as NH2-PEG6-OH, is a monodisperse bifunctional polyethylene glycol derivative. It consists of a primary amino group and a terminal hydroxyl group linked by a hexaethylene glycol chain, serving as an effective molecular linker intermediate for synthesis applications.

This compound is utilized in fine chemical and pharmaceutical research for constructing PEGylated molecules, PROTACs, and antibody-drug conjugates requiring a specific hydrophilic spacer length. Aure Chemical offers reliable sourcing and documentation support for global customers working with this specialty PEG derivative.

Basic Information

CAS No.	39160-70-8
EC No.	828-877-2
Linear Formula	H₂N-(CH₂CH₂O)₆-H
Molecular Weight	281.35 g/mol
Appearance	Colorless to light yellow oily liquid or viscous liquid
Melting Point	Not available (typical reference)
Boiling point	388.0 ± 37.0 °C (Predicted)
Density	1.083 ± 0.06 g/cm³ (Predicted)
Solubility	Soluble in water, DMSO, DCM, and DMF
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place under inert atmosphere. Protect from moisture and light. Recommended storage at 2-8°C.
Chemical Structure

Key Applications

• PEG linker intermediate: Provides a defined six-unit PEG spacer with terminal amino and hydroxyl groups for the construction of PROTAC molecules and non-cleavable ADC linkers.

• Bioconjugation research: The primary amine supports efficient coupling to carboxylic acids and activated esters, while the hydroxyl group allows further modification of biomolecules.

• Fine chemical intermediate: Acts as a versatile building block for incorporating hydrophilic polyether chains into complex organic molecules during specialty synthesis.

• Process development: Facilitates laboratory and pilot-scale route optimization involving precise PEG-based linkers for pharmaceutical and specialty chemical projects.

• Laboratory research: Widely used in medicinal chemistry laboratories to explore PEGylation effects and develop functional conjugates with controlled spacer lengths.

Why Work with Aure Chemical for Amino-PEG6-alcohol

• Consistent product quality: High-purity Amino-PEG6-alcohol is sourced through established channels with routine quality coordination to meet fine chemical specifications.

• Flexible global supply: We support laboratory, pilot, and bulk procurement needs with stable export logistics and flexible shipping arrangements worldwide.

• SDS and COA support: Comprehensive product documentation including SDS and COA is available upon request to facilitate regulatory review and international procurement.

• Packaging and technical service: Responsive technical communication and assistance with appropriate packaging selection based on order quantity and product characteristics.

Packaging and Storage

• Packaging: Supplied in laboratory-scale sealed containers or sample bottles for small quantities; bulk volumes available in suitable HDPE drums. Customized liquid packaging options can be arranged upon request.

• Storage: Store in a tightly closed container in a cool, dry, well-ventilated area under inert atmosphere. Protect from moisture and light. Long-term storage recommended at 2-8°C.

• Handling of opened containers: After opening, protect the product from air and moisture exposure. Use contents promptly and reseal the container tightly for remaining material.

Safety and Handling

• General handling: Work in a well-ventilated area or chemical fume hood. Follow standard laboratory practices for handling organic compounds containing amine and alcohol functional groups.

• Personal protection: Wear suitable protective gloves, safety goggles, and protective clothing to prevent skin and eye contact during handling and transfer operations.

• Documentation review: Consult the current Safety Data Sheet (SDS) before handling, storage, or transportation to ensure all necessary precautions are followed.