Amino-PEG5-alcohol CAS 34188-11-9

Aure Chemical Supplies Amino-PEG5-alcohol CAS 34188-11-9 for PEG Linker and Specialty Synthesis

Amino-PEG5-alcohol (CAS 34188-11-9), also known as NH2-PEG5-OH, is a monodisperse bifunctional polyethylene glycol derivative featuring a terminal primary amine and a terminal hydroxyl group connected by a pentaethylene glycol spacer. This structure positions it as a valuable molecular linker intermediate in organic synthesis and bioconjugation research.

It finds application in the development of PROTACs, antibody-drug conjugates, and other PEGylated compounds where a defined hydrophilic spacer is required. Aure Chemical provides reliable sourcing support for this fine chemical intermediate, along with necessary documentation for international customers.

Basic Information

CAS No.	34188-11-9
EC No.	Not available
Linear Formula	H₂N-(CH₂CH₂O)₅-H
Molecular Weight	237.29 g/mol
Appearance	Colorless to light yellow liquid or oily liquid
Melting Point	Not available (typical reference)
Boiling point	346.3 ± 32.0 °C (Predicted)
Density	1.077 ± 0.06 g/cm³ (Predicted)
Solubility	Soluble in water, DMSO, DMF, and DCM
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and light. Recommended storage at 2-8°C.
Chemical Structure

Key Applications

• PEG linker intermediate: Serves as a defined five-unit PEG spacer with amino and hydroxyl end groups for the assembly of PROTAC molecules and non-cleavable ADC linkers.

• Bioconjugation research: The amino functionality allows conjugation to carboxylic acid-containing biomolecules, while the hydroxyl group permits additional derivatization.

• Fine chemical intermediate: Functions as a building block for introducing hydrophilic polyether segments into complex organic structures during specialty synthesis.

• Process development: Supports laboratory and pilot-scale efforts in optimizing synthetic routes that incorporate precise PEG-based linkers.

• Laboratory research: Commonly utilized in medicinal chemistry settings for exploring PEGylation strategies and structure-property relationships in drug candidates.

Reliable Supply and Support from Aure Chemical

• Consistent product quality: High-purity Amino-PEG5-alcohol is sourced through established channels with routine quality coordination to meet fine chemical specifications.

• Flexible global supply: We support laboratory, pilot, and bulk procurement needs with stable export logistics and flexible shipping arrangements worldwide.

• SDS and COA support: Comprehensive product documentation including SDS and COA is available upon request to facilitate regulatory review and international procurement.

• Packaging and technical service: Responsive technical communication and assistance with appropriate packaging selection based on order quantity and product characteristics.

Packaging and Storage

• Packaging: Available in small laboratory quantities in sealed containers and sample bottles; larger volumes supplied in suitable HDPE drums. Customized liquid packaging can be arranged based on order size and requirements.

• Storage: Store in a tightly closed container in a cool, dry, well-ventilated place. Protect from moisture and light. Long-term storage recommended at 2-8°C or lower.

• Handling of opened containers: Once opened, minimize exposure to air and moisture. Use promptly and reseal the container tightly to maintain product integrity.

Safety and Handling

• General handling: Work in a well-ventilated area or fume hood. Follow standard procedures for handling organic liquids and amines.

• Personal protection: Use appropriate personal protective equipment such as gloves, safety goggles, and lab coat to avoid contact with skin and eyes.

• Documentation review: Review the latest SDS prior to any handling, storage, or transport activities.