Ethanolamine and Amino Alcohol Derivatives for Fine Chemical Synthesis
Ethanolamine and amino alcohol derivatives are hydroxy-functional amine intermediates used in fine chemical synthesis, API intermediate synthesis and specialty organic chemistry. These molecules contain both amine functionality and hydroxyl groups, giving them useful reactivity for downstream derivatization and process design.
The presence of nitrogen and oxygen functionality within the same structure allows these intermediates to participate in reactions such as alkylation, acylation, esterification, etherification, salt formation or other controlled transformations, depending on the target synthesis route and process conditions.
This product group belongs to the broader family of amine derivatives for API synthesis and specialty chemical intermediates, alongside aminopropanediols, tertiary amino alcohols, ether diamines, amino-PEG linkers and chloroalkylamine intermediates.
What Are Ethanolamine and Amino Alcohol Derivatives?
Ethanolamine derivatives are compounds based on hydroxyethyl amine structures. The nitrogen atom may be primary, secondary, tertiary or further substituted depending on the molecule. Amino alcohol derivatives are a broader group of compounds containing both amine and alcohol functionality within the same structure.
From a structural perspective, these intermediates combine amine reactivity with hydroxyl functionality. The amine group can support alkylation, acylation, salt formation or further nitrogen-based transformations, while the hydroxyl group may support esterification, etherification, chain extension or additional functionalization.
For sourcing and procurement teams, ethanolamine and amino alcohol derivatives are usually evaluated according to assay, water content, related amine impurities, residual solvents, appearance, odor, physical state, hygroscopicity, packaging, storage requirements, dangerous goods classification and documentation availability.
Why These Intermediates Matter in Fine Chemical Synthesis
The dual reactivity of ethanolamine and amino alcohol derivatives makes them useful in synthetic routes where both nitrogen incorporation and hydroxyl functionality are required. Depending on the molecule, these intermediates may be selected for polarity adjustment, hydrogen-bonding capability, salt formation behavior, steric effects or further derivatization.
Typical application areas include API intermediate synthesis, fine chemical synthesis, surfactant intermediate synthesis, specialty organic intermediates and selected functional chemical routes. The exact use depends on structure, specification and downstream process requirements.
In commercial sourcing, impurity profile, residual amines, water content and batch-to-batch consistency are important. These parameters may affect reaction performance, color, downstream purification and customer acceptance, so specification confirmation should be completed before order placement.
Product Comparison Table
The following products represent common ethanolamine and amino alcohol derivative structures used in specialty intermediate sourcing.
| Product | CAS No. | Structural Type | Typical Sourcing Focus | Product Page |
|---|---|---|---|---|
| 2-(Ethylamino)ethanol | 110-73-6 | Secondary ethanolamine derivative | Assay, water content, residual amines, color, odor | 2-(Ethylamino)ethanol CAS 110-73-6 |
| 2-(tert-Butylamino)ethanol | 4620-70-6 | Hindered secondary amino alcohol | Assay, related amines, moisture, color, transport classification | 2-(tert-Butylamino)ethanol CAS 4620-70-6 |
| N-Butylethanolamine | 111-75-1 | N-alkyl ethanolamine derivative | Purity, odor, water content, packaging compatibility | N-Butylethanolamine CAS 111-75-1 |
| 2-[2-(tert-Butylamino)ethoxy]ethanol | 87787-67-5 | Ether-linked amino alcohol | Assay, water content, physical state, ether-chain structure | 2-[2-(tert-Butylamino)ethoxy]ethanol CAS 87787-67-5 |
| N,N,N’,N’-Tetrakis(2-hydroxyethyl)ethylenediamine | 140-07-8 | Multi-hydroxyethyl diamine derivative | Hydroxyl functionality, appearance, water content, impurity profile | N,N,N’,N’-Tetrakis(2-hydroxyethyl)ethylenediamine CAS 140-07-8 |
| Bicine / N,N-Bis(2-hydroxyethyl)glycine | 150-25-4 | Bis-hydroxyethyl amino acid derivative | Assay, appearance, pH-related properties, storage stability | Bicine CAS 150-25-4 |
| 3-Methylamino-1-propanol | 42055-15-2 | Secondary amino propanol derivative | Purity, water content, physical state, related amines | 3-Methylamino-1-propanol CAS 42055-15-2 |
Key Product Groups
Secondary Ethanolamine Derivatives
Secondary ethanolamine derivatives include 2-(ethylamino)ethanol, N-butylethanolamine and 3-methylamino-1-propanol. These compounds contain both secondary amine and hydroxyl functionality, making them useful where amino alcohol structure is required in downstream synthesis.
Sourcing teams typically focus on assay, water content, related amine impurities, residual solvents, color, odor, physical state, packaging compatibility and transport classification. For liquid amino alcohol products, packaging tightness and odor control may also be important during handling and shipment.
Bulky Amino Alcohol and Ether Amino Alcohol Derivatives
Bulky amino alcohol derivatives include 2-(tert-butylamino)ethanol and 2-[2-(tert-butylamino)ethoxy]ethanol. These structures introduce a tert-butylamino group, while the ether-linked derivative also contains additional oxygen functionality in the side chain.
Such products may be selected where steric effects, amino alcohol functionality or ether-chain structure are required in a synthesis route. Buyers reviewing this group may also compare related tertiary amino alcohols and hindered amine bases, especially when steric or base-related requirements overlap.
Multi-Hydroxyethyl Amine and Buffer-Type Chemical Intermediates
Multi-hydroxyethyl amine derivatives include N,N,N’,N’-tetrakis(2-hydroxyethyl)ethylenediamine and Bicine / N,N-bis(2-hydroxyethyl)glycine. These products contain multiple hydroxyethyl groups or amino acid-type functionality, making them relevant as hydroxy-functional amine intermediates, chelating-agent-related intermediates, buffer-type chemical intermediates or functional chemical building blocks.
For these materials, sourcing considerations may include assay, appearance, water content, pH-related properties where relevant, metal ion levels where required, storage conditions and documentation availability. Any special specification should be confirmed before quotation or order placement.
Sourcing Considerations for Ethanolamine and Amino Alcohol Derivatives
When sourcing ethanolamine and amino alcohol derivatives, buyers usually need to evaluate both technical specification and practical supply conditions. Products within this group may differ in odor, corrosiveness, hygroscopicity, viscosity, physical state, storage requirements and transport classification.
Purity and assay: Confirm the required assay level and analytical method based on downstream process needs.
Water content: Moisture may affect reaction performance, storage stability or customer acceptance.
Related amines: Related ethanolamines, amino alcohols or other amine impurities may need to be reviewed.
Residual solvents: Residual solvent control may be important for fine chemical and intermediate applications.
Color and appearance: Appearance requirements should be confirmed according to customer specification and intended use.
Odor: Many amino alcohol derivatives have characteristic amine odor, which may affect packaging and handling requirements.
Physical state: Confirm whether the material is liquid, solid, viscous liquid, low-melting solid or solution.
Hygroscopicity and moisture sensitivity: Some hydroxy-functional amines may require moisture-protective packaging or tighter storage control.
Storage conditions: Storage should be reviewed according to SDS, supplier recommendation and product stability.
Packaging compatibility: Packaging should match product properties, order quantity and transport requirements.
Dangerous goods classification: Transport classification should be confirmed case by case according to the latest SDS and shipment route.
COA and SDS: COA and SDS may be available for confirmed products, subject to product and supplier confirmation.
Lead time: Availability may depend on production schedule, warehouse stock, batch release and inland transport.
Export documentation: Export documents, HS code reference and transport documents should be reviewed before shipment.
Batch consistency: Repeat-purchase projects may require stable specification, impurity profile and appearance.
Packaging and Logistics
Packaging for ethanolamine and amino alcohol derivatives should be selected according to physical state, odor, corrosiveness, hygroscopicity, hazard classification, supplier recommendation and order quantity. Liquid products may be supplied in suitable small bottles, small drums, 25 L drums, 200 L drums or other packaging formats depending on product properties and supplier confirmation.
Solid products may be supplied in 25 kg fiber drums with double PE liner or other suitable packaging where appropriate. Some products may require sealed packaging, moisture protection, corrosion-resistant packaging, specific transport labels or temperature consideration depending on SDS and transport classification.
Sea, air, courier, LCL or FCL shipment options must be evaluated case by case. Some products may not be suitable for certain transport routes or small-volume courier shipment depending on dangerous goods classification, package size and destination requirements.
Common trade terms may include FOB China port, FCA warehouse, CFR/CIF destination port or DAP destination where applicable. Import clearance, local duties, taxes and destination compliance should be confirmed by the buyer or their appointed import agent.
Ethanolamine and Amino Alcohol Derivatives Available from Aure Chemical
Based on the above application segment, Shandong Aure Chemical can support sourcing and supply coordination for selected ethanolamine and amino alcohol derivatives used in organic intermediate and specialty chemical synthesis. Related products include 2-(ethylamino)ethanol, 2-(tert-butylamino)ethanol, N-butylethanolamine, 2-[2-(tert-butylamino)ethoxy]ethanol, N,N,N’,N’-tetrakis(2-hydroxyethyl)ethylenediamine, Bicine and 3-methylamino-1-propanol.
For suitable products, Aure Chemical can help review product name, CAS number, target specification, quantity, packaging requirement, destination and required documentation. Available support may include quotation, specification confirmation, COA/SDS coordination, packaging review and export logistics discussion.
Product availability, lead time, specification, packaging, documentation and shipment feasibility are subject to product and supplier confirmation. Buyers are encouraged to provide clear technical and commercial requirements before quotation.
Request Information or Quotation
To discuss ethanolamine or amino alcohol derivative requirements, please provide the following information when sending an inquiry:
Product name and CAS number
Target purity, assay or specification
Required quantity for sample, trial order, batch order or annual consumption
Destination port or delivery address
Preferred trade term, such as FOB China port, FCA warehouse, CFR/CIF destination port or DAP destination where applicable
Preferred packaging or drum size
Required documents, such as COA, SDS, TDS, product overview or supplier questionnaire
Expected purchase schedule or project timeline
Contact Aure Chemical for Ethanolamine and Amino Alcohol Derivatives