1,8-Diamino-3,6-dioxaoctane CAS 929-59-9

Aure Chemical Supplies 1,8-Diamino-3,6-dioxaoctane CAS 929-59-9 for PEG Linker and Specialty Synthesis

1,8-Diamino-3,6-dioxaoctane, also known as NH2-PEG3-NH2, is a short hydrophilic diamine featuring a diethylene glycol spacer between two primary amino groups. This structure makes it a practical building block for introducing flexible, water-compatible linkages in organic molecules. Aure Chemical provides sourcing support for this functional PEG derivative to customers engaged in pharmaceutical intermediate development and specialty synthesis projects worldwide.

The terminal amino groups enable straightforward coupling reactions such as amide bond formation, while the PEG3 chain imparts hydrophilicity and conformational flexibility. It is commonly handled as a liquid and finds use in laboratory-scale research through to pilot and bulk process development. Product specifications typically range from 95% to 99%+ purity depending on grade requirements.

Basic Information

CAS No.	929-59-9
EC No.	213-206-7
Linear Formula	H₂N(CH₂CH₂O)₂CH₂CH₂NH₂
Molecular Weight	148.20 g/mol
Appearance	Colorless to pale yellow liquid
Melting Point	Not available (typical reference)
Boiling point	120 °C at 2 mmHg (lit.)
Density	~1.0 g/mL at 20 °C (lit.)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and incompatible materials.
Chemical Structure

Key Applications

• PEG linker intermediate: The short PEG3 chain with terminal amino groups serves as a hydrophilic spacer for constructing PEGylated molecules and bioconjugates in pharmaceutical research.

• Molecular linker intermediate: Functions as a flexible building block for linking functional moieties through amide or other coupling reactions in organic synthesis.

• Bioconjugation research: Enables efficient attachment of biomolecules or labels via its primary amino end groups in medicinal chemistry and surface modification studies.

• Fine chemical intermediate: Applied in the preparation of advanced intermediates where a short, water-soluble diamine spacer is required for molecular design.

• Process development: Supports route scouting, optimization, and scale-up work for custom synthesis projects involving PEG-based functional materials.

Why Work with Aure Chemical for 1,8-Diamino-3,6-dioxaoctane

• Consistent product quality: High-purity material with reliable batch consistency suitable for fine chemical synthesis and research applications.

• Flexible global supply: Support for laboratory, pilot-scale, and bulk quantities through established international logistics and export channels.

• SDS and COA support: Product documentation including SDS and COA is available to assist with quality review, regulatory compliance, and procurement processes.

• Packaging and technical service: Responsive communication and assistance with packaging selection based on order size and product handling requirements.

Packaging and Storage

• Packaging: Available in small quantity sample bottles, 1 L to 25 L HDPE drums, and larger bulk containers depending on customer requirements.

• Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area away from moisture and incompatible substances.

• Handling of opened containers: Minimize exposure to air and moisture after opening; use contents promptly and reseal containers carefully.

• Bulk supply: Flexible packaging and delivery arrangements available for pilot and commercial-scale orders.

Safety and Handling

• General handling: Handle under conditions of good industrial hygiene. Avoid unnecessary contact with skin, eyes, and clothing during transfer and processing.

• Personal protection: Use appropriate personal protective equipment such as chemical-resistant gloves, safety goggles, and protective clothing as needed.

• Documentation review: Always consult the latest Safety Data Sheet before handling, storage, transportation, or use of the material.

• Compatibility: Review compatibility with process materials and avoid contact with strong oxidizing agents or conditions that may affect amine functionality.