Shandong Aure Chemical Co., Ltd.

1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine CAS 57227-28-8

Persistent supply for specialized needs
1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine CAS 57227-28-8
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1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine CAS 57227-28-8

Synonyms: 4-(3-Chloropropyl)-1-piperazineethanol; 2-(4-(3-Chloropropyl)piperazin-1-yl)ethanol; 4-(3-CHLOROPROPYL)-1-PIPERAZINE ETHANOL; N-(3-Chloropropyl)-N'-(2-hydroxyethyl)piperazine; 1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine; Piperazine, 1-(3-chloropropyl)-4-(2-hydroxyethyl)-

Shandong Aure Chemical Co., Ltd. is one of the leading suppliers of 1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine in China.

We can provide customized requirements in terms of product purity, packaging specifications, and other aspects.

Please contact us to obtain the latest product information.

Product Details

Aure Chemical Delivers Reliable 1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine (CAS 57227-28-8) at Consistent Quality

1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine is a bifunctional piperazine featuring a reactive 3-chloropropyl chain on one nitrogen and a hydroxyethyl group on the other. The terminal chlorine enables nucleophilic substitution while the hydroxyl provides a site for further esterification or etherification.

This structure makes it a valuable intermediate for attaching modified piperazine units in complex molecules. Aure Chemical maintains consistent purity suitable for fine chemical synthesis and pharmaceutical development.


Basic Information

CAS No.57227-28-8
EC No.Not available
Linear FormulaC9H19ClN2O
Molecular Weight206.71
AppearanceColorless to light yellow liquid or low-melting solid
Melting PointNot available (typical reference)
Boiling pointNot available (typical reference)
DensityNot available (typical reference)
SolubilitySoluble in common organic solvents
Storage ConditionsKeep in a cool, dry place, sealed tightly, protected from light and moisture
Chemical StructureMolecular Structure of 1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine

Key Applications

  • Organic synthesis intermediate: Serves as a bifunctional alkylating agent for introducing chloropropyl-hydroxyethylpiperazine moieties through nucleophilic substitution.

  • Fine chemical intermediate: Used in the preparation of specialty piperazine derivatives for industrial applications.

  • Pharmaceutical intermediate: Key building block in the synthesis of pharmaceutical compounds requiring functionalized piperazine side chains.

  • Laboratory research: Applied in medicinal chemistry for exploring new bioactive molecules and structural modifications.

  • Process development: Supports route optimization and scale-up of multi-step syntheses involving selective piperazine functionalization.


Aure Chemical: Your Reliable Partner

  • Consistent product quality: Aure Chemical delivers material with controlled purity and batch-to-batch consistency tailored for organic intermediate applications.

  • Stable global supply: We offer reliable international logistics and flexible supply options from research quantities to larger scale orders.

  • SDS and COA support: Full safety data sheets and certificates of analysis are provided upon request to meet quality and regulatory requirements.

  • Packaging and technical service: Customized packaging in 1 kg to 25 kg sizes with inner liners, supported by responsive technical communication.

Packaging, Logistics & Compliance Capabilities

Aure Chemical provides flexible packaging solutions, compliant logistics arrangements, and controlled storage practices to support laboratory-scale, pilot-scale, and commercial-scale global supply.

Packaging Options

  • 25 kg / 50 kg bags (fiber drum, aluminum bag, HDPE drum)
  • 100 kg / 200 kg steel or HDPE drums
  • 500 kg / 1000 kg IBC containers
  • Bulk liquids in ISO tank containers
  • Customized packaging upon request

Transportation Modes

  • Sea freight (FCL / LCL)
  • Air freight for selected products
  • Road and rail transportation
  • Dangerous & non-dangerous cargo handling
  • Incoterms: EXW, FOB, CFR, CIF, DAP, DDP

Storage & Handling

  • Dry, cool, and well-ventilated warehouses
  • Segregation by hazard class
  • FIFO inventory management
  • Temperature-controlled storage if required
  • Regular inspection & labeling control

Documentation & Compliance

  • Safety Data Sheet (SDS)
  • Certificate of Analysis (COA)
  • Dangerous Goods Declaration (DGD)
  • Packing List & Commercial Invoice
  • IMDG / IATA / ADR compliant labeling

For packaging customization or logistics consultation, please contact us.


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