1-(2-Hydroxyethyl)piperazine CAS 103-76-4
Aure Chemical Supplies 1-(2-Hydroxyethyl)piperazine CAS 103-76-4 for Specialty Synthesis
1-(2-Hydroxyethyl)piperazine (CAS 103-76-4), also known as N-(2-hydroxyethyl)piperazine or 1-piperazineethanol, is an intermediate used in pharmaceutical and fine chemical synthesis. Its structure contains a hydroxyethyl group attached to one piperazine nitrogen and a secondary amine at the other ring nitrogen, providing both hydroxyl and amine functionality for further transformation. Aure Chemical supports China sourcing, product specification review, quality documentation, and export coordination for this intermediate.
For synthesis planning, buyers can review the reported product purity, piperazine content, water content, and color against their reaction and downstream purification requirements. Product grade, packaging, availability, and shipping terms are confirmed for each enquiry.
Basic Information
| CAS No. | 103-76-4 |
|---|---|
| EC No. | 203-142-3 |
| Molecular Formula | C₆H₁₄N₂O |
| Molecular Weight | 130.19 g/mol |
| Appearance | Colorless or light yellow liquid |
| Boiling Point | 246 °C (literature reference) |
| Density | 1.061 g/mL at 25 °C (literature reference) |
| Water Solubility | Completely miscible (reference property) |
| Storage Conditions | Refer to the current product SDS and the storage instructions confirmed for the supplied grade and packaging. |
| Chemical Structure |  |
Boiling point, density, and water solubility are general reference properties, separate from the reported quality specifications and batch results below.
Reference Quality Analysis
The following quality parameters provide a technical reference for evaluating 1-(2-hydroxyethyl)piperazine, including appearance, product purity, piperazine content, color, and water content. For synthesis applications, the piperazine impurity and water limits should be reviewed alongside the main-component purity.
| Test Item | Reported Specification | Reference Result |
|---|---|---|
| Appearance | Colorless or light yellow liquid | Conforms |
| N-Hydroxyethylpiperazine (Anh), % | ≥99.50 | 99.94 |
| Piperazine (Anh), % | ≤0.20 | 0.01 |
| Color, HAZ | ≤30 | 5 |
| Water, % | ≤0.30 | 0.03 |
The designation “Anh” is retained as reported for the product and piperazine entries. The report does not define this designation or specify the test methods; confirm the analytical basis and methods when agreeing purchase specifications.
These reported specifications and analytical results are provided for preliminary technical evaluation. The reference results apply to one production lot and should not be interpreted as guaranteed values for every shipment. Please contact Aure Chemical to confirm the applicable quality requirements and request the relevant batch-specific Certificate of Analysis (COA) before ordering.
Key Applications
Organic and fine chemical synthesis: The remaining secondary amine provides a site for selected N-alkylation or N-acylation routes, while the terminal hydroxyl group can be used for further derivatization. Reaction conditions and selectivity depend on the target structure.
Pharmaceutical intermediates: A building block for selected synthesis routes requiring a hydroxyethyl-substituted piperazine unit. Buyers should define the purity, impurity, and documentation requirements for the intended intermediate.
Buffer synthesis: A building block for the preparation of selected piperazine-based buffering agents used in cell culture. The finished buffer has its own composition and quality requirements.
Research and route development: Can be evaluated in route screening and intermediate development involving hydroxyethylpiperazine structures, with piperazine impurity and moisture requirements defined for the intended reaction.
Related Heterocycle Intermediates
1-(2-Hydroxyethyl)piperazine CAS 103-76-4 belongs to Aure Chemical's piperazine derivatives for API building blocks series within our broader heterocycle derivatives for pharmaceutical intermediates portfolio.
Buyers sourcing hydroxyethyl or N-substituted piperazine derivatives may also review related piperazine intermediates such as 1-(2-Hydroxyethyl)-4-methylpiperazine CAS 5464-12-0, 1,4-Bis(2-hydroxyethyl)piperazine CAS 122-96-3, and 4-Methyl-1-piperazinepropanol CAS 5317-33-9.
For related hydroxyethyl nitrogen heterocycles outside the piperazine series, buyers may also compare 4-(2-Hydroxyethyl)morpholine CAS 622-40-2, 1-(2-Hydroxyethyl)piperidine CAS 3040-44-6, and Aure Chemical's morpholine derivatives for pharmaceutical intermediates.
Aure Chemical: China Sourcing and Export Support
Specification review: Aure Chemical supports review of product identity, purity, piperazine content, color, and water requirements against the available quality documentation.
Supplier coordination: Availability, lead time, and order quantity are confirmed according to the requested product grade, supplier availability, and destination requirements.
SDS and COA support: Available safety data sheets and batch-specific certificates of analysis can be provided for review, subject to the proposed grade and production lot.
Packaging and export logistics: Packaging, labeling, documentation, and shipping terms are coordinated according to the agreed order and destination requirements.
Safety, Handling & Documentation
Request the current SDS for the grade being supplied before storage, handling, or shipment. Use it to determine the applicable hazard classification, protective equipment, storage conditions, incompatibilities, and transport requirements. Confirm the applicable storage instructions and any retest interval for the supplied grade and packaging. The reference quality analysis on this page does not replace the SDS or the batch-specific COA.
Packaging
25 L HDPE drum
Final packaging, capacity and net weight are confirmed in the quotation and order.
