Anisole CAS 100-66-3

Anisole (Methoxybenzene) CAS 100-66-3 from Aure Chemical

Anisole, also known as methoxybenzene or methyl phenyl ether, CAS 100-66-3, is an aromatic ether containing a methoxy group attached to a benzene ring. It is used as an organic synthesis solvent and as an intermediate in selected fine chemical and fragrance-related routes. Aure Chemical supports sourcing from China, specification review, quality documentation, and international export coordination for customers evaluating technical-grade anisole.

Basic Information of Anisole

The reference COA describes a technical-grade, transparent colorless liquid. General physical properties are listed separately from the batch-specific quality analysis below.

CAS No.	100-66-3
EC No.	202-876-1
Molecular Formula	C₇H₈O
Condensed Formula	C₆H₅OCH₃
Molecular Weight	108.14 g/mol
Reference Grade	Technical grade
Appearance	Clear, colorless liquid
Odor	Aromatic (reference description)
Melting Point	-37 °C (reference property)
Boiling Point	154 °C at 1013 hPa (reference property)
Density	0.995 g/mL at 25 °C (literature reference)
Solubility	Slightly soluble in water; miscible with methanol and acetone (reference information)
Chemical Structure

Purity and water content should be reviewed against the intended process requirements. The reference COA does not qualify the product as an anhydrous solvent or establish suitability for food, cosmetic, or other regulated end uses.

Reference Quality Analysis

The following quality parameters provide a technical reference for evaluating anisole, covering appearance, purity determined by gas chromatography, and water content. The quality limits are reported under an enterprise product standard in the reference COA.

Technical Grade

The reported purity requirement is ≥99.5%; 99.9% is the result for the reference batch. The COA identifies GC for the purity determination but does not specify the water-test method. Percentages and comparison signs are reproduced as reported.

These analytical values describe one production lot and are provided for preliminary technical evaluation; they should not be interpreted as guaranteed results for every shipment. Contact Aure Chemical to confirm the applicable grade, specifications, analytical methods, and purchasing requirements, and request the relevant batch-specific COA before ordering.

Applications of Anisole

Anisole's aromatic ether structure supports its use as a reaction medium and as a starting material for selected aromatic intermediates. Application suitability depends on the reaction, impurity tolerance, and required water content.

• Organic synthesis solvent: Used as an aprotic organic reaction medium in selected fine chemical processes. Solvent suitability should be assessed against substrate compatibility, operating conditions, and the required impurity and water limits.

• Fine chemical and pharmaceutical intermediate: Provides a methoxyaromatic starting structure for selected intermediate syntheses. Suitability for a particular pharmaceutical or specialty chemical route requires process-specific material qualification.

• Fragrance-related chemical synthesis: Used in selected routes to aroma and fragrance chemicals. Any proposed use in flavor, food, or cosmetic formulations requires a separately confirmed grade and applicable regulatory assessment.

For moisture-sensitive or organometallic synthesis, confirm the allowable water content and qualify the material for the intended route. The technical-grade reference results should not be taken as evidence of anhydrous-solvent performance.

Aure Chemical: Anisole Sourcing and Export Support

Aure Chemical is a chemical trading and export supply company supporting customers sourcing anisole from China. Supply arrangements are reviewed against the requested grade, quantity, available documentation, and destination requirements.

• Specification review: Compare purity, appearance, and water-content requirements with the available product documentation. Confirm any additional impurity or application-specific requirements separately.

• Quality documentation: Coordinate the available batch COA and current SDS, including clarification of analytical methods and reporting basis where needed.

• Supplier coordination: Confirm availability, order quantity, packaging options, and lead time for the proposed supply.

• International export logistics: Coordinate labeling, shipping documentation, and transport arrangements according to the supplied product's current SDS and destination requirements.

Safety, Handling & Documentation

The following safety information is a reference based on published SDS information for anisole, CAS 100-66-3. Obtain and review the current SDS for the supplied grade before handling or arranging transport.

• Reference GHS classification: Flammable liquids (Category 3); specific target organ toxicity, single exposure (Category 3), with the central nervous system identified as the target.

• Reference hazard statements: H226: Flammable liquid and vapor. H336: May cause drowsiness or dizziness. Confirm the applicable categories and labels from the current product SDS.

• Handling: Avoid vapor exposure and skin or eye contact. Follow the current SDS and workplace assessment for ventilation, protective equipment, control of ignition sources, and grounding and bonding during transfer.

• Storage: Keep containers tightly closed in a cool, well-ventilated location away from ignition sources. Follow the current SDS for storage conditions and incompatible materials.

• Reference transport information: UN 2222, Anisole, Class 3, Packing Group III. Confirm the final shipping classification, packaging, and transport requirements against the current SDS for the supplied product.

• Documentation: Request the relevant batch COA and current SDS before ordering. Confirm destination-specific regulatory documentation requirements separately.

The following pictograms are shown for reference; the required labels must follow the current SDS for the supplied grade.