High-Purity 4-(Trifluoromethyl)benzonitrile CAS 455-18-5 from Aure Chemical: Stable Supply & Documentation Support
4-(Trifluoromethyl)benzonitrile is an aromatic nitrile featuring a para-trifluoromethyl substituent on the benzene ring. The electron-withdrawing CF3 group enhances the reactivity of the nitrile towards nucleophilic additions and reductions in controlled synthetic pathways.
It serves primarily as a versatile building block in pharmaceutical intermediate production. Aure Chemical ensures consistent quality suitable for precise fine chemical applications.
Basic Information
| CAS No. | 455-18-5 |
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| EC No. | 207-238-2 |
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| Linear Formula | C8H4F3N |
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| Molecular Weight | 171.12 |
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| Appearance | Colorless to white crystals or crystalline powder |
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| Melting Point | 37-41 °C (lit.) |
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| Boiling point | 83 °C/12 mmHg (lit.) |
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| Density | 1.27 g/cm³ (Predicted) |
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| Solubility | Insoluble in water; soluble in organic solvents like ethanol, acetone (typical reference) |
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| Storage Conditions | Keep in a tightly closed container in a cool, dry place, room temperature |
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| Chemical Structure |  |
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Key Applications
Pharmaceutical intermediate: Critical precursor in the synthesis of fluvoxamine, a selective serotonin reuptake inhibitor used in antidepressant therapy.
API intermediate: Employed in preparation of active pharmaceutical ingredients incorporating trifluoromethylated aromatic nitriles.
Aromatic compound synthesis: Facilitates construction of fluorinated benzene derivatives through nitrile transformations.
Laboratory research: Utilized in medicinal chemistry for exploring trifluoromethyl-substituted analogs.
Process development: Applied in route optimization and scale-up for efficient fine chemical manufacturing.
Aure Chemical: Your Reliable Partner
Consistent product quality: High purity and batch uniformity verified through standard QC methods for reliable performance in synthesis.
Global supply reliability: Stable export capabilities with established logistics for timely delivery across lab to pilot scales.
SDS and COA support: Full documentation including safety data sheets and certificates of analysis provided upon request.
Packaging and technical service: Flexible options such as 1kg/5kg/25kg fiber drums with PE liners combined with professional technical assistance.
