4-(Trifluoromethyl)benzonitrile CAS 455-18-5

Name: 4-(Trifluoromethyl)benzonitrile CAS 455-18-5
Brand: Aure Chemical
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Synonyms: 4-Trifluoromethylbenzonitrile;α,α,α-Trifluoro-p-tolunitrile;4-Cyanobenzotrifluoride;p-Trifluoromethylbenzonitrile;p-Cyanobenzotrifluoride;4-(Trifluoromethyl)phenyl cyanide;Benzonitrile, 4-(trifluoromethyl)-

Shandong Aure Chemical Co., Ltd. is one of the leading suppliers of 4-(Trifluoromethyl)benzonitrile in China.

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Product Details

High-Purity 4-(Trifluoromethyl)benzonitrile CAS 455-18-5 from Aure Chemical: Stable Supply

4-(Trifluoromethyl)benzonitrile is an aromatic nitrile featuring a para-trifluoromethyl substituent on the benzene ring. The electron-withdrawing CF3 group enhances the reactivity of the nitrile towards nucleophilic additions and reductions in controlled synthetic pathways.

It serves primarily as a versatile building block in pharmaceutical intermediate production. Aure Chemical ensures consistent quality suitable for precise fine chemical applications.

Basic Information

CAS No.	455-18-5
EC No.	207-238-2
Linear Formula	C8H4F3N
Molecular Weight	171.12
Appearance	Colorless to white crystals or crystalline powder
Melting Point	37-41 °C (lit.)
Boiling point	83 °C/12 mmHg (lit.)
Density	1.27 g/cm³ (Predicted)
Solubility	Insoluble in water; soluble in organic solvents like ethanol, acetone (typical reference)
Storage Conditions	Keep in a tightly closed container in a cool, dry place, room temperature
Chemical Structure

Key Applications

Pharmaceutical intermediate: A critical precursor in the synthesis of fluvoxamine, a selective serotonin reuptake inhibitor used in antidepressant therapy, and a relevant building block within Aripiprazole and Fluvoxamine intermediates for CNS-related pharmaceutical development.
API intermediate: Employed in the preparation of active pharmaceutical ingredients incorporating trifluoromethylated aromatic nitriles, making it valuable in fluorinated pharmaceutical intermediates and related medicinal chemistry programs.
Aromatic compound synthesis: Facilitates construction of fluorinated benzene derivatives through nitrile transformations in pharmaceutical and fine chemical synthesis.
Laboratory research: Utilized in medicinal chemistry for exploring trifluoromethyl-substituted analogs and fluorinated small-molecule design.
Process development: Applied in route optimization and scale-up for efficient fine chemical manufacturing and pharmaceutical intermediates for API synthesis.

Aure Chemical: Your Reliable Partner

Consistent product quality: High purity and batch uniformity verified through standard QC methods for reliable performance in synthesis.
Global supply reliability: Stable export capabilities with established logistics for timely delivery across lab to pilot scales.
SDS and COA support: Full documentation including safety data sheets and certificates of analysis provided upon request.
Packaging and technical service: Flexible options such as 1kg/5kg/25kg fiber drums with PE liners combined with professional technical assistance.

Packaging, Logistics & Compliance Capabilities

Aure Chemical provides flexible packaging solutions, compliant logistics arrangements, and controlled storage practices to support laboratory-scale, pilot-scale, and commercial-scale global supply.