Aure Chemical Delivers Reliable 4-Chloro-N-Methylpicolinamide (CAS 220000-87-3) at Consistent Quality
4-Chloro-N-methylpicolinamide is a chlorinated pyridine derivative with an N-methyl carboxamide substituent. This structure enables selective nucleophilic aromatic substitution in multi-step synthetic pathways.
It is primarily used in pharmaceutical manufacturing for introducing the picolinamide motif into larger molecules. Aure Chemical offers material suitable for precise intermediate applications in controlled environments.
Basic Information
| CAS No. | 220000-87-3 |
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| EC No. | 606-888-1 |
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| Linear Formula | C7H7ClN2O |
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| Molecular Weight | 170.60 |
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| Appearance | Pale yellow to white solid / powder |
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| Melting Point | 41-43 °C (lit.) |
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| Boiling point | 317.8±27.0 °C (Predicted) |
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| Density | 1.264±0.06 g/cm³ (Predicted) |
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| Solubility | Soluble in methanol; slightly soluble in common organic solvents (typical reference) |
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| Storage Conditions | Keep in dark place, sealed in dry, room temperature |
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| Chemical Structure |  |
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Key Applications
Pharmaceutical intermediate: Critical precursor in the synthesis of sorafenib, a multi-kinase inhibitor for oncology applications.
API intermediate: Used in the preparation of active pharmaceutical ingredients involving substituted pyridine scaffolds.
Heterocyclic synthesis: Facilitates construction of pyridine-based aromatic systems through amide and chloro group transformations.
Process development: Employed in route optimization and scale-up for efficient production of fine chemical intermediates.
Custom synthesis: Applied in tailored projects requiring high-purity chlorinated picolinamides for research purposes.
Aure Chemical: Your Reliable Partner
High product consistency: Maintained through strict quality controls and analytical verification for reproducible performance in intermediate synthesis.
Stable international supply: Supported by reliable logistics networks for timely delivery to global pharmaceutical and fine chemical clients.
Comprehensive documentation: SDS, COA, and other supporting documents supplied as standard to meet regulatory and quality needs.
Technical and packaging flexibility: Expert guidance on applications combined with options like 1kg/5kg/25kg packing in fiber drums or customized formats.
