High-Purity Chloro(triphenylphosphine)gold(I) from Aure Chemical – Your Trusted Source
Chloro(triphenylphosphine)gold(I), AuCl(PPh₃), CAS No. 14243-64-2, is one of the most widely used and versatile Au(I) precatalysts in modern homogeneous gold catalysis. Supplied by Aure Chemical as white to pale yellow crystalline powder with high gold content (approximately 39–40% Au), this air-stable complex features a linear Au(I) center coordinated by chloride and triphenylphosphine ligands. Renowned for its exceptional Lewis acidity and π-activation properties, it serves as the benchmark precursor for gold-catalyzed transformations including hydroamination, cycloisomerization, C–H activation, nucleophilic additions to alkynes, and rearrangements essential to pharmaceutical intermediate synthesis, natural product construction, and fine chemical manufacturing. Its mild reaction conditions, broad functional group tolerance, and ability to generate highly electrophilic Au(I) species make it indispensable in both academic research and industrial applications. Aure Chemical delivers rigorous purity control, low residual impurities, and secure gold sourcing to ensure batch consistency and optimal catalytic performance worldwide.
Basic Information of Chloro(triphenylphosphine)gold(I)
Aure Chemical supplies Chloro(triphenylphosphine)gold(I) as a premium Au(I) precatalyst with verified high gold content and exceptional purity for gold-catalyzed transformations.
| CAS No. | 14243-64-2 |
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| EC No. | 238-115-2 |
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| Chemical Formula | AuCl(P(C₆H₅)₃) |
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| Molecular Weight | 494.10 g/mol |
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| Appearance | White to pale yellow crystalline powder |
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| Odor | Odorless |
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| Melting point | ~200 °C (decomposes) |
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| Boiling point | Not applicable (decomposes) |
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| Density | approx. 2.0–2.2 g/cm³ |
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| Solubility | Insoluble in water; soluble in dichloromethane, chloroform, benzene, toluene, THF |
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| Nature (hazards) | May cause skin and eye irritation, harmful if swallowed or inhaled, toxic to aquatic life with long lasting effects |
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| RIDADR | UN 3077, Environmentally hazardous substance, solid, n.o.s. (Chloro(triphenylphosphine)gold(I)), Class 9, Packing Group III |
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| Chemical Structure |  |
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Aure Chemical offers customizable options including purity grades (99%+ Au basis), air-sensitive packaging under inert atmosphere, and tailored batch sizes to preserve stability for your catalysis or scale-up needs.
Primary Applications of Chloro(triphenylphosphine)gold(I)
AuCl(PPh₃) is a foundational Au(I) precatalyst, readily activated by silver salts or acids to generate highly electrophilic gold species for selective transformations.
Hydroamination & Hydroalkoxylation
Catalyzes efficient addition of amines or alcohols to alkynes and allenes, providing atom-economical routes to enamines, imines, and oxygen heterocycles in pharmaceutical synthesis.
Cycloisomerization & Rearrangements
Enables selective cycloisomerization of enynes, allenynes, and propargylic compounds to form carbocycles and heterocycles with high regio- and stereocontrol.
C–H Activation & Functionalization
Promotes direct C–H functionalization of arenes, heterocycles, and aliphatic substrates, delivering efficient pathways to complex molecules in drug discovery.
Nucleophilic Additions to Unsaturated Bonds
Facilitates gold-catalyzed 1,2- and 1,4-additions to alkynes, allenes, and enones, offering mild conditions and broad functional group compatibility.
Pharmaceutical & Natural Product Synthesis
Widely applied in key steps of API manufacturing and natural product total synthesis, leveraging its high selectivity and mild reaction conditions.
Catalyst Development & Mechanistic Studies
Serves as a standard Au(I) source for ligand screening, counterion effects, and mechanistic investigations in gold catalysis R&D.
Why Choose Aure Chemical for Your Chloro(triphenylphosphine)gold(I) Supply?
Partner with Aure Chemical for AuCl(PPh₃) to access benchmark gold catalysis performance, technical expertise, and dependable precious metal supply for your synthetic needs.
Superior Purity & Stability
Rigorous quality controls ensure high Au content, minimal impurities, and preserved phosphine coordination for maximum catalytic activity.
Secure Precious Metal Sourcing
Transparent, responsible gold procurement with inventory buffering to provide supply stability and competitive pricing.
Technical Catalysis Support
Dedicated specialists offer guidance on activation (Ag salts, acids), substrate scope, reaction optimization, and scale-up for maximum efficiency.
Comprehensive Regulatory Compliance
Full COA, REACH, RoHS, and detailed SDS documentation to facilitate seamless integration into pharmaceutical and fine chemical operations.
Sustainability & Recycling Programs
Ethical sourcing practices and gold recovery/recycling programs aligned with ESG objectives and sustainable chemistry principles.
Hazards Classification
GHS Classification: Acute Toxicity, Oral (Category 4); Skin Irritation (Category 2); Eye Irritation (Category 2A); Aquatic Chronic (Category 3)
Hazard Statements: H302: Harmful if swallowed; H315: Causes skin irritation; H319: Causes serious eye irritation; H413: May cause long lasting harmful effects to aquatic life
UN Number: UN 3077
Hazard Class: 9 (Miscellaneous dangerous substances and articles)
Packing Group: III
GHS07: Exclamation mark (irritant, acute toxicity)
GHS09: Environment (aquatic hazard)
