Allyl Chloroformate CAS 2937-50-0

Aure Chemical Delivers Reliable Allyl Chloroformate (CAS 2937-50-0) at Consistent Quality

Allyl chloroformate is a reactive chloroformate ester that functions as a versatile protecting group reagent and acylating agent in organic chemistry. It readily reacts with amines to form stable Alloc-protected derivatives that can be selectively removed under mild palladium-catalyzed conditions, offering excellent orthogonality in complex synthetic sequences. The compound is moisture sensitive and requires handling under anhydrous conditions to maintain reactivity and prevent decomposition.

Its primary value lies in enabling efficient and selective synthetic routes in pharmaceutical and peptide chemistry where traditional protecting groups may not provide the desired control or compatibility. Aure Chemical provides material with consistent purity to support reproducible results in demanding applications. Storage under inert atmosphere in tightly sealed containers is recommended to preserve product integrity.

Basic Information

CAS No.	2937-50-0
EC No.	220-916-6
Linear Formula	ClCOOCH2CH=CH2
Molecular Weight	120.53 g/mol
Appearance	Colorless liquid with pungent odor
Melting Point	Not available (lit.)
Boiling point	109-110 °C (lit.)
Density	1.134 g/mL at 25 °C (lit.)
RIDADR	UN 1722 Class 6.1 (3, 8) PG I
Chemical Structure

Key Applications

• Protecting group reagent in peptide synthesis: Allyl chloroformate is widely used to introduce the allyloxycarbonyl (Alloc) protecting group for amines, enabling selective deprotection in complex peptide and organic synthesis.

• Pharmaceutical intermediate: It serves as a key reagent in the preparation of active pharmaceutical ingredients and intermediates where temporary protection of amino groups is required during multi-step synthesis.

• Organic synthesis applications: Employed as an acylating agent for the introduction of allyloxycarbonyl functionality in the construction of specialty chemicals and bioactive molecules.

• Medicinal chemistry and drug development: Used in research laboratories for the synthesis of drug candidates and analogs requiring orthogonal protecting group strategies.

• Specialty chemical production: Applied in the manufacture of fine chemicals and functional materials where controlled acylation or protection chemistry is essential.

Aure Chemical: Your Reliable Partner

• High purity specifications and strict batch consistency: Our allyl chloroformate is produced under rigorous quality control to deliver reliable performance in sensitive protecting group chemistry and pharmaceutical synthesis processes.

• Stable export supply supported by established logistics channels: We maintain consistent global availability and coordinate efficient bulk shipments tailored to the requirements of pharmaceutical and fine chemical manufacturers worldwide.

• Complete SDS, COA and dangerous goods documentation available: Full regulatory and safety documentation packages support compliance with international standards for the transport and use of this reactive chemical intermediate.

• Professional technical communication and responsive service: Our experienced team provides dedicated assistance with product application guidance, packaging recommendations, and safe handling practices specific to chloroformate reagents.

Hazards Classification

GHS Classification: Flammable liquids (Category 3) GHS02; Skin corrosion (Category 1B) GHS05; Acute toxicity, inhalation (Category 2) GHS06.

Hazard Statements: H226 - Flammable liquid and vapour. H314 - Causes severe skin burns and eye damage. H330 - Fatal if inhaled.

UN Number: UN 1722 | Hazard Class: 6.1 (Toxic) with subsidiary risks 3 (Flammable liquid) and 8 (Corrosive) | Packing Group: I