High-Purity 15-Crown-5 CAS 33100-27-5 from Aure Chemical: Stable Supply
15-Crown-5 (CAS 33100-27-5) is a macrocyclic polyether widely used in organic synthesis as a selective complexing agent for sodium cations. It functions effectively in phase-transfer catalysis, enabling efficient reactions between aqueous and organic phases while improving ion solubility in non-polar media.
Aure Chemical provides this specialty reagent in high purity suitable for fine chemical manufacturing and laboratory applications. Our consistent supply supports process chemists and researchers requiring reliable performance in coordination chemistry and synthetic methodology development.
Basic Information
| CAS No. | 33100-27-5 |
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| EC No. | 251-379-6 |
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| Linear Formula | C10H20O5 |
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| Molecular Weight | 220.26 |
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| Appearance | Colorless to light yellow clear liquid |
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| Melting Point | -20 °C (lit.) |
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| Boiling point | 93-96 °C at 0.05 mmHg (lit.) |
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| Density | 1.11 g/mL at 20 °C (lit.) |
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| Solubility | Soluble in water and most organic solvents |
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| Storage Conditions | Store under inert gas in a cool, dry place. Hygroscopic; protect from moisture. |
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| Chemical Structure |  |
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Key Applications
Phase-transfer catalysis: 15-Crown-5 is widely used as a phase-transfer catalyst in organic synthesis, selectively complexing sodium ions to enhance anion reactivity in biphasic systems. It is a representative product in Crown Ethers (15-Crown-5 & 18-Crown-6) for Phase Transfer & API Synthesis, where selective cation binding significantly improves reaction efficiency and yield.
Selective ion complexation: Due to its cavity size and binding affinity, 15-Crown-5 exhibits high selectivity for sodium ions, enabling controlled ion transport and coordination in both synthetic and analytical applications. This functionality is a key focus of the crown ether application category.
Fine chemical synthesis: Employed in fine chemical production where cation complexation enhances reaction selectivity, conversion, and overall process performance in specialty syntheses.
Supramolecular and coordination chemistry: Widely applied in research for host–guest chemistry, ion recognition, and supramolecular system design, supporting advanced functional molecule development.
Process development: Supports route optimization and process scale-up in organic synthesis, particularly in reactions requiring efficient ion transport, controlled reactivity, and improved selectivity.
15-Crown-5 belongs to the Crown Ethers for Phase Transfer Catalysis application category and is part of our broader portfolio of Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering crown ethers, ion-complexing agents, and advanced catalytic systems for API and specialty chemical synthesis.
Aure Chemical: Your Reliable Partner
Consistent product quality: Aure Chemical ensures high purity specifications and batch-to-batch consistency for 15-Crown-5 through routine quality control tailored to organic synthesis requirements.
Flexible global supply: Stable international logistics support laboratory, pilot, and bulk procurement with reliable delivery to fine chemical customers worldwide.
SDS and COA support: Full SDS, COA, and regulatory documentation available upon request to facilitate quality review and international procurement.
Packaging and technical service: Flexible packaging in 25L/200L HDPE drum, supported by responsive technical communication for application needs.
